نوع مقاله : مقاله پژوهشی
نویسندگان
1 استادیار، گروه ایمونولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی کرمان، کرمان، ایران.
2 استادیار، مرکز تحقیقات ایمونولوژی بیماریهای عفونی، پژوهشکده علوم پایه پزشکی، دانشگاه علوم پزشکی رفسنجان، رفسنجان، ایران.
3 دانشجوی کارشناسی ارشد، مرکز تحقیقات ایمونولوژی بیماریهای عفونی، پژوهشکده علوم پایه پزشکی، دانشگاه علوم پزشکی رفسنجان، رفسنجان، ایران.
4 دانشیار، مرکز تحقیقات اعتیاد و علوم رفتاری، دانشگاه علوم پزشکی شهید صدوقی یزد، یزد، ایران.
چکیده
کلیدواژهها
عنوان مقاله [English]
نویسندگان [English]
Introduction: Cytokines play an important role in generating and maintaining acquired immunity responses duringpreterm, term, and prolonged pregnancy. It seems that IFN-g levels in the maternal serum and neonatal cord blood are associated with the type of delivery. Accordingly, this study aimed to investigate the cytokine IFN-g concentrations in the maternal serum and neonatal cord blood in term and prolonged deliveries.
Materials and Methods:This descriptive study was conducted on 125 cord blood specimens from neonates born through term and prolonged-pregnancy and the 122 serum samples from their mothers in Rafsanjan Niknafs Maternity in 2018. The IFN-g levels in the maternal serum and neonatal cord blood were measured by enzyme-linked immunosorbent assay (ELISA) and compared by the independent samples t-test.
Results:The results revealed that IFN-g levels were not significantly different between prolonged-pregnancy mothers and their neonates compared with term mothers and their neonates, but a weak positive correlation was found between IFN-g in cord blood of term neonates and the age of the mothers (r = 0.240, p=0.05).
Conclusion: The results showed that IFN-g has not effect on prolonged-pregnancy
کلیدواژهها [English]