بررسی رابطه فاکتورهای باروری با سرطان پستان در زنان 35 تا 70 ساله: نتایج فاز اول مطالعه کوهورت شاهدیه در استان یزد

نوع مقاله : مقاله پژوهشی

نویسندگان

1 کارشناس ارشد، مرکز تحقیقات مدل‌سازی داده‌های سلامت، دانشکده بهداشت، دانشگاه علوم پزشکی و خدمات بهداشتی درمانی شهید صدوقی یزد، یزد، ایران.

2 استاد، مرکز تحقیقات مدل‌سازی داده‌های سلامت، دانشکده بهداشت، دانشگاه علوم پزشکی و خدمات بهداشتی درمانی شهید صدوقی یزد، یزد، ایران.

3 دانشیار، گروه داخلی، دانشکده پزشکی، بیمارستان شهید صدوقی یزد، دانشگاه علوم پزشکی و خدمات بهداشتی درمانی شهید صدوقی یزد، یزد، ایران.

4 استاد، گروه رادیولوژی دهان، دانشکده دندانپزشکی، دانشگاه علوم پزشکی و خدمات بهداشتی درمانی شهید صدوقی یزد، یزد، ایران.

5 دانشجوی کارشناسی ارشد، گروه ارگونومی، دانشکده بهداشت، دانشگاه علوم پزشکی و خدمات بهداشتی درمانی شهید صدوقی یزد، یزد، ایران.

چکیده

مقدمه: شناسایی عوامل خطر سرطان پستان در بررسی وضعیت نظام مراقبت‌های سرطان نقش مهمی دارد. مطالعه حاضر با هدف تعیین رابطه فاکتورهای باروری با سرطان پستاندر زنان 35 تا 70 ساله شرکت‌کننده در مطالعه کوهورت شاهدیه یزد انجام شد.
مواد و روش‌ها: این مطالعه توصیفی است و به صورت مقطعی در سال­های 96-1394 انجام شد. تعداد 4820 زن 35 تا 70 ساله شامل 25 نفر (6/0 درصد) با سابقه ابتلا به سرطان پستان و 4795 نفر (4/99 درصد) بدون سابقه ابتلا به سرطان پستان مورد مطالعه قرار گرفتند. در این مطالعه از داده­های جمع­آوری شده در فاز اول مطالعه کوهورت شاهدیه در استان یزد استفاده شد. داده­های مورد استفاده در این مطالعه شامل اطلاعات دموگرافیک و تاریخچه باروری زنان بود. داده‌ها با استفاده از آزمون‌های آماری مجذور کای، t مستقل و رگرسیون لجستیک تجزیه و تحلیل شدند.
یافته‌ها: نتایج نشان داد شیردهی کمتر از 11 ماه 78/2 برابر، هورمون درمانی بعد از یائسگی 07/2 برابر، سن شروع منوپوز بعد از 46 سال 71/1 برابر، داشتن سابقه سقط 63/1 برابر ، مصرف قرص‌های ضدبارداری 59/1 برابر، سن شروع قاعدگی کمتر از 13 سال 49/1 برابر و داشتن اضافه وزن و چاقی 45/1 برابر شانس ابتلا به سرطان پستان را افزایش می‌دهد.
نتیجه‌گیری: طبق نتایج به دست آمده شیردهی کمتر از 11 ماه ، هورمون درمانی بعد از یائسگی و سن شروع منوپوز بعد از 46 سال و مصرف قرص‌های ضد بارداری از مهم‌ترین عوامل خطر سرطان پستان بودند.

کلیدواژه‌ها


عنوان مقاله [English]

The Relationship between Reproductive Factors and Breast Cancer in Women Aged 35 to 70 Years: Results of the First Phase of Shahedyeh Cohort Study in Yazd Province

نویسندگان [English]

  • M Momayyezi 1
  • H Fallahzadeh 2
  • MR Mirjalili 3
  • F Ezoddini 4
  • M Mirzaei 2
  • VS Anoosheh 5
1 MSc, Center for Healthcare Data Modeling, School of public health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
2 Prof, Center for Healthcare Data Modeling, Dept of Biostatistics and Epidemiology, School of public health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
3 Associate Prof, Dept of Internal Medicine, School of Medicine, Shahid Sadoughi General Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
4 Prof, Dept of Oral and Maxillofacial Radiology, School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
5 MSc Student, Dept of Ergonomics, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
چکیده [English]

Introduction: The identification of risk factors for breast cancer has an important role in examining the status of cancer care system. Therefore, the present study was conducted to determine the relationship between reproductive factors and breast cancer in women aged 35 to 70 years based on the data from the first phase of Shahedyeh Cohort Study (SCS) in Yazd province.
Materials and Methods: This descriptive, cross-sectional study was conducted using the data from the first phase of SCS in Yazd province in 2015-2017. In this study, 4820 women aged 35 to 70 years were investigated, including 25 (0.6%) with a history of breast cancer and 4795 (99.4%) without any history of breast cancer. The data used in this study included demographic and reproductive histories of the women. The data were analyzed using Chi-square, t-test, and logistic regression.
Results: The results showed that breastfeeding for less than 11 months increases the chance of breast cancer by 2.78 times, hormone therapy after menopause by 2.07 times, the onset age of menopause ≥46 by 1.71 times, having a history of abortion by 1.63 times, taking contraceptive pills by 1.59 times, age at menarche ≤13 by 1.49 times, and being overweight and obesity by 1.45 times.
Conclusion: According to the results, breastfeeding for less than 11 months, hormone therapy after menopause, the onset age of menopause after 46 years, and taking contraceptive pills were the most important risk factors for breast cancer.

کلیدواژه‌ها [English]

  • risk factors
  • breast cancer
  • Shahedyeh cohort
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