نویسندگان
استادیار گروه نورولوژی، مرکز تحقیقات علوم اعصاب، پژوهشکده نوروفارماکولوژی ، دانشگاه علوم پزشکی کرمان، کرمان ، ایران
چکیده
کلیدواژهها
عنوان مقاله [English]
نویسندگان [English]
 Introduction: Diabetes mellitus is the most common cause of peripheral nerve involvement. It has been shown that oxidative stress plays an important role in the development of neurological and behavioral disorders. The purpose of the present study was to evaluate the effect of IMOD on treatment neuropathic pain in streptozotocin-induced diabetic rats.  Material and Methods : Thirty two male rats were divided into four groups including control, sham, diabetic recipient IMOD and solvents. Diabetes was induced by intraperitoneal injection of Streptozotocin (45mg/kg) dissolved in 0.1 M citrate buffer. Thereafter, the diabetic rats were given Imod (40 mg dose in milliliters) orally for two weeks followed by performing Tail flick and Hot plate tests. one-way anova was used to evaluate and analysis of the data .  Result: In Hotplate and Tail Flick tests, solvent and sham groups showed significant decrease in the time of thermal pain response compared to the control group. In the Imod-treated group the response time of Hotplate was increased compared to sham and solvent groups (P
کلیدواژهها [English]
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