تأثیر ۱۲ هفته تمرین استقامتی بر میزان گلوکز، انسولین خون و ساختار قلب موش‌های دیابتی نوع 2

نویسندگان

1 دانشجوی دکتری، گروه فیزیولوژی ورزشی، دانشکده تربیت بدنی، دانشگاه آزاد اسلامی واحد تهران مرکزی، تهران، ایران

2 استادیار، گروه فیزیولوژی ورزشی، دانشکده تربیت بدنی، دانشگاه آزاد اسلامی واحد تهران مرکزی، تهران، ایران

3 استاد، گروه فیزیولوژی ورزشی، دانشکده تربیت بدنی، دانشگاه آزاد اسلامی واحد تهران مرکزی، تهران، ایران

4 استادیار، گروه ویروس شناسی، انستیتو پاستور ایران، تهران، ایران

چکیده

مقدمه: دیابت نوع 2 به عنوان یک فاکتور خطر برای بیماری قلبی به شمار می­رود و سهم عمده­ای در مرگ­ومیر ناشی از بیماری­های قلبی- عروقی دارد، هدف از پژوهش حاضر بررسی تأثیر ۱۲ هفته تمرین استقامتی بر میزان گلوکز، انسولین خون و ساختار قلب موش های دیابتی نوع 2 است.

مواد و روش ­ها: ۱۶ سر موش نر نژاد ویستار با میانگین وزن20 ± 200 گرم به صورت تصادفی به دو گروه، دیابتی کنترل و دیابتی استقامتی تقسیم و در شرایط آزمایشگاهی نگهداری شدند، گروه تجربی، 12 هفته به تمرین استقامتی پرداختند. پس از دوره تمرینی فاکتورهای مورد نظر که شامل: وزن موش­ها ، وزن قلب، وزن بطن چپ، درصد وزن قلب به وزن بدن، درصد وزن بطن چپ به وزن قلب، ضربان قلب استراحت، میزان گلوگز، انسولین و شاخص مقاومت به انسولین اندازه گیری شد. برای تجزیه و تحلیل آماری داده­ها از آزمون  t مستقل استفاده شد.  

یافته­ ها: نتایج بدست آمده نشان داد که بین میانگین وزن بطن چپ (005/0p=)، درصد وزن قلب به وزن بدن (001/0p=)، میزان گلوگز (000/0p=)، انسولین (000/0p=) و ضربان قلب حالت استراحت (003/0p=) در گروه دیابتی استقامتی نسبت به گروه دیابتی کنترل تفاوت معنی داری وجود داشت (05/0p<).

نتیجه‌گیری: با توجه به نتایج تحقیق حاضر، به نظر می­رسد تمرین استقامتی بر میزان گلوکز، انسولین و ساختار قلب
دیابتی­ ها مؤثر است و می­تواند به عنوان یک روش مداخله­ای تأثیرگذار مورد توجه قرار گیرد.  

کلیدواژه‌ها


عنوان مقاله [English]

The Effects of 12 week Endurance Training on glucose amount, Blood insulin and Heart Structure in type 2 diabetic Rats

نویسندگان [English]

  • R Mohammadi 1
  • H Matin Homaee 2
  • MA Azarbayjani 3
  • K Baesi 4
1 PhD student, Dept. of Exercise Physiology, Faculty of Physical Education, Islamic Azad University, Central Tehran Branch, Tehran, Iran
2 Assistant Professor, Dept. of Exercise Physiology, Faculty of Physical Education, Islamic Azad University, Central Tehran Branch, Tehran, Iran
3 Prof. Dept. of Exercise Physiology, Faculty of Physical Education, Islamic Azad University, Central Tehran Branch, Tehran, Iran
4 Assistant Prof., Dept. of Virology, Pasteur Institute of Iran, Tehran, Iran
چکیده [English]

Introduction: Type 2 diabetes as a factor for heart disease is a major contributor to deaths due to cardiovascular disease, The aim of this study was to evaluate The effects of 12 week endurance training on serum glucose, insulin and heart structure in type 2 diabetic Rats. 

Materials and methods: 16 male Wistar rats with an average weight of 200 ± 20 g were randomly divided into two groups, diabetic control (n = 8) and diabetic endurance (n = 8) and were kept in vitro, The experimental group received endurance training for 12 weeks. The following factors were measured: Body weight ( BW), heart weight (HW), left ventricular mass (LHW), percentage of heart weight to body weight (HW / BW), heart weight, left ventricular weight (LVW / HW), resting heart rate (RHR ), amount of glucose, insulin, insulin resistance index, In order to analyze the data, independent sample t-test at p ≤ 0/05 significance level was used.

Results: The results showed that there was a significant difference between the average left ventricle weight (P= 0/005), the percentage of the heart weight to the body weight (P= 0/001), amount of glucose (P= 0/000), insulin (P= 0/000), and resting heart rate (P= 0/003), between the endurance diabetic group and the control diabetic group (p<0/05).

Conclusion: Based on the results of the present study, it seems that endurance training affects the amount of blood glucose and insulin and the heart structure. Therefore, it can be considered as an effective interference method.

کلیدواژه‌ها [English]

  • Endurance Training
  • Diabetes
  • Heart structure
  • insulin
  1. De Luca A, Stefani L, Pedrizzetti G, Pedri S, Galanti G. The effect of exercise training on left ventricular function in young elite athletes. Cardiovascular ultrasound 2011;9(1):1-9.
  2. Sheikhzadeh F, Khajehnasiri N, Khojasteh SMB, Soufi FG, Dastranj A, Taati M. The effect of regular moderate exercise, on cardiac hypertrophy and blood glucose level in diabetic adult male rats. International Research Journal of Applied and Basic Sciences 2013; 6 (4): 499-503.
  3. Schoenfeld BJ. The mechanisms of muscle hypertrophy and their application to resistance training. The Journal of Strength & Conditioning Research 2010;24(10):2857-72.
  4. Barauna VG, Rosa KT, Irigoyen MC, De Oliveira EM. Effects of resistance training on ventricular function and hypertrophy in a rat model. Clinical medicine & research 2007;5(2):114-20.
  5. Daryanoosh F, Tanideh N, Bazgir B, Alizadeh H. Effect of aerobic trainings on heart’s functioned and structure in diabetic Sprague-dawely albino species male rats. Res Applied Exercise Physiology 2010; 6 (12): 59-72.[Persian]
  6. Hildick-Smith D, Shapiro L. Echocardiographic differentiation of pathological and physiological left ventricular hypertrophy. Heart 2001;85(6):615-9.
  7. Kong SW, Bodyak N, Yue P, Liu Z, Brown J, Izumo S, et al. Genetic expression profiles during physiological and pathological cardiac hypertrophy and heart failure in rats. Physiological Genomics 2005;21(1):34-42.
  8. Mihl C, Dassen W, Kuipers H. Cardiac remodelling: concentric versus eccentric hypertrophy in strength and endurance athletes. Netherlands Heart Journal 2008;16(4):129-33.
  9. McMullen JR, Jennings GL. Differences between pathological and physiological cardiac hypertrophy: novel therapeutic strategies to treat heart failure. Clinical and Experimental Pharmacology and Physiology 2007;34(4):255-62.
  10. Middleton N, Shave R, George K, Whyte G, Hart E, Atkinson G. Left ventricular function immediately following prolonged exercise: A meta-analysis. Medicine and Science in Sports and Exercise 2006;38(4):681-7.
  11.  Ahmadiasl N, Najafipour H, Soufi FG, Jafari A. Effect of short-and long-term strength exercise on cardiac oxidative stress and performance in rat. Journal of physiology and biochemistry 2012;68(1):121-8. [Persian]
  12. Pluim BM, Zwinderman AH, van der Laarse A, van der Wall EE. The athlete’s heart a meta-analysis of cardiac structure and function. Circulation 2000;101(3):336-44.
  13. Obert P, Mandigout S, Vinet A, N'guyen L, Stecken F, Courteix D. Effect of aerobic training and detraining on left ventricular dimensions and diastolic function in prepubertal boys and girls. International journal of sports medicine 2001;22(2):90-6.
  14. Rawlins J, Bhan A, Sharma S. Left ventricular hypertrophy in athletes. European Heart Journal-Cardiovascular Imaging 2009;10(3):350-6.
  15. Badalzadeh R, Shaghaghi M, Mohammadi M, Dehghan G, Mohammadi Z. The Effect of Cinnamon Extract and Long-Term Aerobic Training on Heart Function, Biochemical Alterations and Lipid Profile Following Exhaustive Exercise in Male Rats. Advanced pharmaceutical bulletin 2014;4(Suppl 2):515-20. [Persian]
  16. Kazemi F, Zahedi AS. The Correlation of Plasma Levels of Apelin-13 with Insulin Resistance Index and Plasma Leptin of Diabetic Male Rats after 8-Week Aerobic Exercise. Arak Medical University Journal 2015; 18(99): 51-60. [Persian]
  17. Fathi M, Gharakanlou R, Rezaei R. The effect of endurance training on left ventricle serum response factor gene expression in Wistar male rats. Journal of Shahrekord University of Medical Sciences. 2015;17(1):78-86. [Persian]
  18. Rahbar S, Ahmadiasl N. Effect of Long Term Regular Resistance Exercise on Heart Function and Oxidative Stress in Rats. Journal of Ardabil University of Medical Sciences 2012;12(3):256-64. [Persian]
  19. Soufi FG, Saber MM, Ghiassie R, Alipour M. Role of 12-week resistance training in preserving the heart against ischemia-reperfusion-induced injury. Cardiol J 2011;18(2):140-5. [Persian]
  20. Wang Y, Wisloff U, Kemi OJ. Animal models in the study of exercise-induced cardiac hypertrophy. Physiological research 2010;59(5):633-44.
  21. Gaeini A, Kazem F, Mehdiabadi J, Shafiei-Neek L. The effect of 8-week aerobic interval training and a detraining period on left ventricular structure and function in non-athlete healthy men. Zahedan Journal of Research in Medical Sciences 2012;13(9):16-20. [Persian]
  22. Hayward R, Lien C-Y. Echocardiographic Evaluation of Cardiac Structure and Function during Exercise Training in the Developing Sprague–Dawley Rat. Journal of the American Association for Laboratory Animal Science 2011;50(4):454-61.
  23. Mahmudzadeh T, Saghebjoo M, Seghatol Eslami A, Hedayati M. Effect of Aerobic Training and Pistacia Atlantica Extract Consumption on Pancreatic Β-Cells function in Streptozotocin-induced Diabetic rats. Iranian journal of Diabetes and Metabolism 2014;13(3):252-62.[Persian]
  24.  Schultz RL, Swallow JG, Waters RP, Kuzman JA, Redetzke RA, Said S, et al. Effects of excessive long-term exercise on cardiac function and myocyte remodeling in hypertensive heart failure rats. Hypertension 2007;50(2):410-6.
  25. Boudina S, Abel ED. Diabetic cardiomyopathy, causes and effects. Reviews in Endocrine and Metabolic Disorders 2010;11(1):31-9.
  26. Taji TA, Mogharnasi M.The Effect of 10 Week Resistane Exercise Traning on Serum Levels of Nesfatin-1  and Insulin Resistance Index in Woman With Type 2 Diabetes. Iranian journal of Diabetes and Metabolism 2015; 3 (14): 179-88.[Persian]