Effects of Eight Weeks of Personalized Alternate Sprint and Combined Exercise (strength and aerobic) Training on Blood Level of Glycated Hemoglobin (HbA1c) and Insulin Resistance in Women with Type 2 Diabetes

Document Type : Original Article


1 Msc, Dept of physiology, Shahrekord University, Shahrekord, Iran.

2 2- Assistant prof, Dept of exercise physiology, Shahrekord University, Shahrekord, Iran.

3 Associate prof, Dept of exercise physiology, Shahrekord University, Shahrekord, Iran.


Introduction: Physical activity ‘as a very important part of a healthy lifestyle, is entangled with the therapeutic management of type 2 diabetes. The purpose of this study was to investigate the effects of eight weeks of personalized alternate sprint and combined exercise training on blood level of glycosylated hemoglobin A1C and insulin resistance in women with type 2 diabetes.
Materials and Methods: In this quasi-experimental study, fifty-two female patients with type 2 diabetic were assigned to three groups; sprint interval training SIT, combined training and control group according to the HbA1c levels. The combined Group  received alternatively 2 sessions per week of endurance training with 70% of one repetition maximum and aerobic exercise training with 60% -70% of maximum heart rate and 1 session per week of only aerobic exercise training. The SIT group received 3 sessions per week of 4-10 reps 30-second Wingate test on the ergometer with maximum effort. Fasting blood glucose, serum insulin and HbA1c levels were then measured. Data analyzing was performed using dependent t-test and covariance and LSD method.
Results: The findings of this stusy showed that while the HbA1c concentrations reduced significantly in both SIT (p=0.002) and combined groups (p=0.006), serum insulin levels had a significant increase  in these two groups;  p<0.001) and pConclusion: Results indicated that individualized exercise training courses may have a positive   effect on bodily structure and blood glucose control in women with type 2 diabetes.


  1. Simpson SH, Corabian P, Jacobs P, Johnson JA. The cost of major comorbidity in people with diabetes mellitus. CMAJ 2003;168(13):1661-7.
  2. Jorge MLMP, de Oliveira VN, Resende NM, Paraiso LF, Calixto A, Diniz ALD, et al. The effects of aerobic, resistance, and combined exercise on metabolic control, inflammatory markers, adipocytokines, and muscle insulin signaling in patients with type 2 diabetes mellitus. Metabolism 2011;60(9):1244-52.
  3. Lambers S, Van Laethem C, Van Acker K, Calders P. Influence of combined exercise training on indices of obesity, diabetes and cardiovascular risk in type 2 diabetes patients. Clinical Rehabilitation 2008;22(6):483-92.
  4. Mann S, Beedie C, Jimenez A. Differential effects of aerobic exercise, resistance training and combined exercise modalities on cholesterol and the lipid profile: review, synthesis and recommendations. Sports Medicine 2014;44(2):211-21.
  5. Habibi N, Marandi S. Effect of 12 weeks of yoga practice on glucose, insulin and triglycerides serum level in women with diabetes type II. JGMS 2014;15(4):1-7.
  6. Wood WA, Phillips B, Smith-Ryan AE, Wilson D, Deal AM, Bailey C, et al. Personalized home-based interval exercise training may improve cardiorespiratory fitness in cancer patients preparing to undergo hematopoietic cell transplantation. Bone marrow transplantation 2016;51(7):967-72.
  7. Little JP, Gillen JB, Percival ME, Safdar A, Tarnopolsky MA, Punthakee Z, et al. Low-volume high-intensity interval training reduces hyperglycemia and increases muscle mitochondrial capacity in patients with type 2 diabetes. JAP 2011;111(6):1554-60.
  8. Grech M, Chaney D. Screening for type 2 diabetes and pre-diabetes in general practice: a descriptive study of Maltese practices. PCD 2014;8(3):224-30.
  9. Mannarino M, Tonelli M, Allan GM. Screening and diagnosis of type 2 diabetes with HbA1c. CFP 2013;59(1):42.
  10. Larose J, Sigal R, Khandwala F, Kenny G. Comparison of strength development with resistance training and combined exercise training in type 2 diabetes. SJMSS 2012;22(4):45-54.
  11. Davis JN, Tung A, Chak SS, Ventura EE, Byrd-Williams CE, Alexander KE, et al. Aerobic and strength training reduces adiposity in overweight Latina adolescents. MSSE 2009;41(7):1494-1503.
  12. Karavirta L, Häkkinen K, Kauhanen A, Arija-Blazquez A, Sillanpää E, Rinkinen N, et al. Individual responses to combined endurance and strength training in older adults. MSSE 2011;43(3):484-90.
  13. Gibala MJ, Little JP, Van Essen M, Wilkin GP, Burgomaster KA, Safdar A, et al. Short‐term sprint interval versus traditional endurance training: similar initial adaptations in human skeletal muscle and exercise performance. The Journal of physiology. 2006;575(3):901-11.
  14. Hovanloo F, Arefirad T, Ahmadizad S. Effects of sprint interval and continuous endurance training on serum levels of inflammatory biomarkers. JDMD 2013;12(1):22.
  15. Roubenoff R, Hughes VA. Sarcopenia: current concepts. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2000;55(12):M716-M24.
  16. Hansen D, Dendale P, Jonkers R, Beelen M, Manders R, Corluy L, et al. Continuous low-to moderate-intensity exercise training is as effective as moderate-to high-intensity exercise training at lowering blood HbA1c in obese type 2 diabetes patients. Diabetologia 2009;52(9):1789-97.
  17. Castaneda C, Layne JE, Munoz-Orians L, Gordon PL, Walsmith J, Foldvari M, et al. A randomized controlled trial of resistance exercise training to improve glycemic control in older adults with type 2 diabetes. Diabetes care 2002;25(12):2335-41.
  18. Snowling NJ, Hopkins WG. Effects of different modes of exercise training on glucose control and risk factors for complications in type 2 diabetic patients. Diabetes care 2006;29(11):2518-27.
  19. Alizadeh Z, Kordi R, MJ H-ZA, Mansournia MA. The effects of continuous and intermittent aerobic exercise on lipid profile and fasting blood sugar in women with a body mass index more than 25 kg/m2: A randomized controlled trial. TUMS 2011;69(4):253-9.[Persian]
  20. Choi K, Kim Y-B. Molecular mechanism of insulin resistance in obesity and type 2 diabetes. KJIM 2010;25(2):119-29.
  21. Kadoglou N, Fotiadis G, Kapelouzou A, Kostakis A, Liapis C, Vrabas I. The differential anti‐inflammatory effects of exercise modalities and their association with early carotid atherosclerosis progression in patients with type 2 diabetes. Diabetic Medicine. 2013;30(2):41-50.
  22. Cuff DJ, Meneilly GS, Martin A, Ignaszewski A, Tildesley HD, Frohlich JJ. Effective exercise modality to reduce insulin resistance in women with type 2 diabetes. Diabetes care. 2003;26(11):2977-82.
  23. Perri MG, Anton SD, Durning PE, Ketterson TU, Sydeman SJ, Berlant NE, et al. Adherence to exercise prescriptions: effects of prescribing moderate versus higher levels of intensity and frequency. Health Psychology2002;21(5):452-8.