Community Health Journal

Community Health Journal

Investigating the relationship between IFN-γ levels in the maternal serum and neonatal cord blood in term and prolonged deliveries in Rafsanjan Niknafs Maternity in 2018

Document Type : Original Article

Authors
R Nosratabadi 1
M Kazemi Arababadi 2
M Mortazavi 2
M Houra 3
R Bidaki 4
F Nazem-kazerani 2
1 Assistant Prof, Dept of Immunology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
2 Assistant Prof, Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
3 MSc student, Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
4 Associate Prof, Research Center of Addiction and Behavioral Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
10.22123/chj.2020.182909.1280
Abstract
Introduction: Cytokines play an important role in generating and maintaining acquired immunity responses duringpreterm, term, and prolonged pregnancy. It seems that IFN-g levels in the maternal serum and neonatal cord blood are associated with the type of delivery. Accordingly, this study aimed to investigate the cytokine IFN-g concentrations in the maternal serum and neonatal cord blood in term and prolonged deliveries.
Materials and Methods:This descriptive study was conducted on 125 cord blood specimens from neonates born through term and prolonged-pregnancy and the 122 serum samples from their mothers in Rafsanjan Niknafs Maternity in 2018. The IFN-g levels in the maternal serum and neonatal cord blood were measured by enzyme-linked immunosorbent assay (ELISA) and compared by the independent samples t-test.
Results:The results revealed that IFN-g levels were not significantly different between prolonged-pregnancy mothers and their neonates compared with term mothers and their neonates, but a weak positive correlation was found between IFN-g in cord blood of term neonates and the age of the mothers (r = 0.240, p=0.05).
Conclusion: The results showed that IFN-g has not effect on prolonged-pregnancy
Keywords
Interferon Gamma
Term Delivery
Prolonged delivery
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