سلامت جامعه

سلامت جامعه

بررسی تأثیر تحریک مکرر مغناطیسی فراقشری بر فعالیت مغزی و اضطراب در بیماران مرد مبتلا به اختلال اضطراب فراگیر

نوع مقاله : مقاله پژوهشی

نویسندگان
1 دانشیار، دانشکده طراحی، دانشگاه هنر اسلامی تبریز، تبریز، ایران.
2 استادیار، دانشکده علوم تربیتی، دانشگاه فرهنگیان، تهران، ایران.
10.22123/chj.2025.479221.2126
چکیده
مقدمه: امواج مغزی در بیماران مبتلا به اختلال اضطراب به شکل نابهنجاری فعالیت می­کنند. پژوهش حاضر با هدف تعیین اثربخشی تحریک مکرر مغناطیسی فراقشری بر فعالیت مغزی و اضطراب در بیماران مرد مبتلا به اختلال اضطراب فراگیر انجام شد.
مواد و روش­ها: در این پژوهش نیمه­آزمایشی، جامعه آماری، مردان مبتلا به علایم اختلال اضطراب فراگیر مراجعه­کننده به مراکز روانپزشکی شهر تبریز در سال 1403 (تعداد تقریبی 200) بودند. تعداد 30 نفر به صورت هدفمند انتخاب و به روش تصادفی به دو گروه مساوی آزمایش و کنترل تقسیم شدند. گروه­ها، از نظر امواج بتا و تتا منطقه PZ و شدت اضطراب ارزیابی شدند. گروه آزمایش به مدت 30 جلسه، تحت درمان (مداخله در ناحیه پشتی جانبی قشر پیش­پیشانی نیمکره چپ) قرار گرفت. برای گروه کنترل مداخله­ای انجام نشد. داده­ها توسط آمار توصیفی و آزمون تحلیل کوواریانس چندمتغیره تحلیل گردید.
یافته ­ها: میانگین و انحراف معیار نمره پیش­آزمون و پس­آزمون اضطراب گروه آزمایش 34/3±53/39 و 98/3±76/27 (001/0>p) و گروه کنترل 75/3±36/38 و 71/3±32/38 بود (47/0>p). میانگین و انحراف معیار نمره پیش­آزمون و پس­آزمون بتا PZ گروه آزمایش 56/4±12/43 و 23/3±19/39 (001/0>p) و گروه کنترل 34/4±54/42 و 76/4±65/43 محاسبه شد (71/0>p). میانگین و انحراف معیار نمره پیش­آزمون و پس­آزمون تتا PZ گروه آزمایش 65/2±19/11 و 56/44±2/5 (001/0>p) و گروه کنترل 12/2±75/10 و 73/2±29/11 بود (12/0>p).  
نتیجه­ گیری: به­نظر می­رسد تحریک مکرر مغناطیسی فراقشری بر فعالیت مغزی و اضطراب بیماران تأثیرگذار باشد. بنابراین، می­توان از تحریک مکرر مغناطیسی فراقشری به عنوان درمانی مؤثر برای کاهش اضطراب در بیماران مبتلا به اختلال اضطراب فراگیر استفاده نمود.
 
کلیدواژه‌ها

عنوان مقاله English

Studying the Effect of Repetitive Transcortical Magnetic Stimulation on Brain Activity and Anxiety in Male Patients with Generalized Anxiety Disorder

نویسندگان English

y movahedi 1
A bayat 2
1 Associate Prof., Dept. of Design, Tabriz Islamic Art University, Tabriz, Iran.
2 Assistant Prof., Faculty of Educational Sciences, Farhangian University, Tehran, Iran.
چکیده English

Introduction: Studies have shown that brain waves in anxious patients operate abnormally. The present study was conducted with the aim of determining the effectiveness of repetitive transcortical magnetic stimulation on brain activity and anxiety in male patients with generalized anxiety disorder.
Materials and Methods: In the present quasi-experimental study, the statistical population was all male patients with symptoms of generalized anxiety disorder referred to psychiatric centers in Tabriz in 2024, approximately 200 men. Both experimental and control groups were evaluated in terms of beta and theta waves of the PZ region and also the severity of anxiety, and then the experimental group was treated for 30 sessions. The intervention was performed in the dorsolateral region of the left prefrontal cortex. The control group did not receive any intervention. Descriptive statistics and multivariate analysis of covariance were used to analyze the data.
Results:The mean and standard deviation of the pre-test and post-test anxiety scores of the experimental group were 39.53±3.34 and 76.27±3.98, respectively (p<0.001) and for the control group they were 38.36±3.75 and 38.32±3.71, respectively (p<0.47). The mean and standard deviation of the pre-test and post-test beta PZ scores of the experimental group were 43.12±4.56 and 39.19±3.23, respectively (p<0.001) and for the control group they were 42.54±4.34 and 43.65±4.76, respectively (p<0.71). The mean and standard deviation of the pre-test and post-test PZ theta scores of the experimental group were 11.19±2.65 and 56.44±2.5, respectively (p<0.001) and for the control group they were 10.75±2.12 and 11.29±2.73, respectively (p<0.12).
Conclusion:It seems that repetitive transcortical magnetic stimulation can affect brain activity and anxiety in patients. Therefore, repetitive transcortical magnetic stimulation can be used as an effective treatment for reducing anxiety in patients with generalized anxiety disorder.

کلیدواژه‌ها English

Brain stimulation
Anxiety
Delta
Beta
  1. Fortuna L R, Brown I C, Woods G G L, Porche M. V. The impact of COVID-19 on anxiety disorders in youth: Coping with stress, worry, and recovering from a pandemic. CAPCNA 2023; 32(3): 531-542.
  2. Hallam C, Simmonds-Buckley M, Kellett S, Greenhill B, Jones A. The acceptability, effectiveness, and durability of cognitive analytic therapy: Systematic review and meta-analysis. PP 2021; 94(1): 8-35.
  3. Jashnani Z, Ghamari M, Kashani Vahid L. Presenting a model of the tendency to self-harming behaviors of teenagers on cyberspace addiction with the mediation of cognitive emotion regulation. PDMD 2024; 2(4): 127-135.
  4. Liu Q, Zhou B, Zhang X, Qing P, Zhou X, Zhou F, & et al. Abnormal multi-layered dynamic cortico-subcortical functional connectivity in major depressive disorder and generalized anxiety disorder. JPR 2023; 167(12): 23-31.
  5. Moore E W G, Petrie T A, Slavin L E. College student-athletes' COVID-19 worry and psychological distress differed by gender, race, and exposure to COVID-19–related events. JAH 2022; 70(4): 559-566.
  6. Power N, Kellett S & Gaskell C. Effectiveness of cognitive analytic therapy for mixed anxiety and depression in the context of borderline traits: A quasi-experimental single case design evaluation. JPI 2023; 33(1): 34-46.
  7. Reyhani S, Ahovan M. The effectiveness of emotional schema therapy on regulating emotions and reducing high-risk behaviors in female adolescents . RBS 2024; 22(1): 137-149.[Persian]
  8. Stefan S, Stroian P, Fodor L, Matu S, Nechita D, Boldea I, et al. An online contextual schema therapy workshop for social anxiety symptoms – A randomized controlled trial. JCBS 2023; 29(3): 67-75.
  9. Zainal N H, Newman M G. Inflammation mediates depression and generalized anxiety symptoms predicting executive function impairment after 18 years. JAD 2022; 296(13): 465-475.
  10. Porcel J, Montalban X. Anticholinesterasics in the treatment of cognitive impairment in Multiple Sclerosis. J Neurol Sci 2006; 245(1-2): 177-81.
  11. Arnett PA, Higginson CI, Randolph JJ. Depression in Multiple Sclerosis: relationship to planning ability. J Int Neuropsychol Soc 2001; 7(6): 665-74.
  12. Moscati A, Flint J, Kendler K S. Classification of anxiety disorders comorbid with major depression: common or distinct influences on risk?. JDA 2016; 33(6): 120-127.
  13. Cantón-Cortés D, Cortés M R, Cantón J. Child Sexual Abuse, Attachment Style, and Depression The Role of the Characteristics of Abuse. JIV 2015; 30(11): 420-436.
  14. Linares L, Jauregui P, Herrero-Fernández D, Estévez A. Mediationg Role of Mindfulness as a Trait Between Attachment Styles and Depressive Symptoms. JP 2016; 7(4): 1-16.

15. Uchenna E, Scott B, Jane N, Terri D, Evan J, Alexandra M, Shauna F, Florin O. The potential of repetitive transcranial magnetic stimulation for addressing sleep difficulties in children with autism – A brief communication. JSM 2024; 118(4):78-80

16.Yuichiro S, Yoshikazu U. Transcranial magnetic stimulation. COBS  2024;  58, (2): 101-396.

17.Chun-Hung C, Shaw-Ji C. Home-based therapy with continuous cranial electrotherapy stimulation after repetitive transcranial magnetic stimulation in a patient with severe depression and anxiety during COVID-19 pandemic: case report and meta-analysis of randomized controlled trials. PRCR  2024; 3(1): 100-220.

18.Renato MendesS, Monara N, Leonardo PeresdeS, Sabrina N, Álison S, AnaV, etal. Hypothesis on the potential of repetitive transcranial magnetic stimulation to modulate neurochemical pathways and circadian rhythm in ADHD. JMH  2024. 189(11): 111-411.

19.Jiajing W, Sheng Z, Xiaoying Z, Lanxiang W, Xinmiao M, Hong J, Chengjie M, Jing C, Chun-feng L. Objective sleep enhancement in Parkinson's disease: A sham-controlled trial of low-frequency repetitive transcranial magnetic stimulation over the right dorsolateral prefrontal cortex. PRD 2024; 126 (8): 107050.

20.Wassermann EM, Lisanby SH. Therapeutic application of repetitive transcranial magnetic stimulation: A review. JCN  2011;112(8):1367-1377.

21.Fitzgerald P B, Hoy K E, Herring S E, McQueen S, Peachey A V, Segrave R A, Daskalakis Z J. A double blind randomized trial of unilateral left and bilateral prefrontal cortex transcranial magnetic stimulation in treatment resistant major depression. JAD 2012; 139(2): 193-198.

22.Baron RA, Mueller BA, Wolfe MT. Self-efficacy and entrepreneurs adoption of unattainable goals: The restraining effects of self-control. JBV 2016;31(1):55-71.

23.Kedzior KK, Rajput V, Price G, Lee J, Martin-Iverson M. Cognitive correlates of repetitive transcranial magnetic stimulation (rTMS) in treatment-resistant depression-a pilot study. BMC Psychiatry  2012;12(1):163-171.

24.Concerto C, Lanza G, Cantone M, Ferri R, Pennisi G, Bella R, et al. Repetitive transcranial magnetic stimulation in patients with drug-resistant major depression: A six-month clinical follow-up study. IJPCP 2015;19(4):252-258.

25.Victor Rossetto B, Gabriel T K, Valquíria Aparecida da S, Luciana MB, at al . Posterior insula repetitive transcranial magnetic stimulation for chronic pain in patients with Parkinson disease – pain type matters: A double-blinded randomized sham-controlled trial. NCCN 2024; 54(5): 102994.

  1. Beck At, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuringdepression. JAMA 1961; 4 (1): 561-571.